![]() Vaccine companies face a number of challenges in scaling up manufacturing to produce hundreds of millions of doses under OWS's accelerated timelines. OWS officials reported that as of January 31, 2021, companies had released 63.7 million doses-about 32 percent of the 200 million doses that, according to OWS, companies with EUAs have been contracted to provide by March 31, 2021. As of January 2021, five of the six OWS vaccine companies had started commercial scale manufacturing. These analyses included assessments of efficacy after individuals were given two doses of vaccine and after they were monitored for about 2 months for adverse events. The two EUAs issued in December 2020 were based on analyses of clinical trial participants and showed about 95 percent efficacy for each vaccine. However, as is done in a non-pandemic environment, all vaccine companies gathered initial safety and antibody response data with a small number of participants before proceeding into large-scale human studies (e.g., phase 3 clinical trials). To meet OWS timelines, some vaccine companies relied on data from other vaccines using the same platforms, where available, or conducted certain animal studies at the same time as clinical trials. Vaccine companies told GAO that the primary difference from a non-pandemic environment was the compressed timelines. FDA issued specific guidance that identified ways that vaccine development may be accelerated during the pandemic. ![]() GAO's analysis of the OWS vaccine candidates' technology readiness levels (TRL)-an indicator of technology maturity- showed that COVID-19 vaccine development under OWS generally followed traditional practices, with some adaptations. For vaccines that received EUA, additional data on vaccine effectiveness will be generated from further follow-up of participants in clinical trials already underway before the EUA was issued. Vaccine Platform Technologies Supported by Operation Warp Speed, as of January 2021Īs of January 30, 2021, five of the six OWS vaccine candidates have entered phase 3 clinical trials, two of which-Moderna's and Pfizer/BioNTech's vaccines-have received an emergency use authorization (EUA) from the Food and Drug Administration (FDA). Clinical trials gather data on safety and efficacy, with more participants in each successive phase (e.g., phase 3 has more participants than phase 2). Vaccine companies also took steps, such as starting large-scale manufacturing during clinical trials and combining clinical trial phases or running them concurrently. For example, OWS selected vaccine candidates that use different mechanisms to stimulate an immune response (i.e., platform technologies see figure). GAO found that OWS and vaccine companies adopted several strategies to accelerate vaccine development and mitigate risk. It’s also noteworthy that I observed (on the second run of the test) that forward motion continued for another 63.92 seconds (if I left the ship to stop of its own accord) or 43.25 (if I pressed the ‘stop the ship’ minus sign on the HUD, three times for urgency)īased on all this the total time for the jump (timed from start to the point where forward motion was 0.0m/s) was between 106.43 seconds to 85.76 seconds.Operation Warp Speed (OWS)-a partnership between the Departments of Health and Human Services (HHS) and Defense (DOD)-aimed to help accelerate the development of a COVID-19 vaccine. I probably need to allow for +/- 0.1 second (the typical reaction time of most people) to allow for the time that it took for me to press the stopwatch stop button. ![]() and stopped this at the point where ‘ Warp Drive Active’ disappeared indicating that the warp drive had stopped operation. I then activated a stopwatch on my iPhone at the same time as selecting/releasing on ‘ Warp to Within 0m’. The readout indicated that I was an orbit distance of 0m from the station. I exited a station, and then immediately stopped my forward motion. The time that the calculator offered up for this jump was 30.709431 seconds.įor the purposes of the test, this is what I did: I entered the following information for my ship: I just tried it though (on a single jump for simplicity’s sake) and I’m not sure that it’s that accurate. ![]() Thanks for posting a link for the EVE warp time calculator This is really cool and almost exactly what I was looking for.
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